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Chinese researchers identify target to develop depression drug using traditional ethnic medicine in Yunnan_我的网站

A |     Tamil cinema is gearing up for a major nostalgia wave as the cult Tamil hit film Padayappa storms back into theatres on 12 December, perfectly timed with Rajinikanth’s 75th birthday and his 50-year milestone in cinema. For fans, this is not just a rerelease but an invitation to revisit a cultural moment that helped define superstardom, fan hysteria, and the sheer spectacle of big screen entertainment.In a newly surfaced behind the scenes video, Rajinikanth looks back on the making of the KS Ravikumar hit with characteristic candour. He recalls being astonished by the sheer volume of women who turned up at cinemas during its original run, something he admits he had never witnessed in his decades long career. For a star known for pan demographic appeal, that detail captures the special emotional tether Padayappa created on release.Rajinikanth Says Padayappa 2 Is Under Serious ConsiderationWhat has amplified fan frenzy even more is Rajinikanth’s confirmation that discussions for Padayappa 2 have begun. Having already been part of sequels like Jailer 2 and 2.0, he said he strongly felt the world of Padayappa still had unexplored dimensions.He added that the proposed sequel would shift its gaze entirely to Neelambari. Ramya Krishnan’s iconic antagonist continues to be one of Tamil cinema’s most celebrated characters, remembered for her intensity, elegance, and fierce emotional complexity. Built around her vow to avenge Padayappa even through another birth, the potential storyline has already ignited rampant speculation among fans.Rajinikanth shared that the creative team is currently shaping the narrative and that the new chapter, if finalised, will retain the festive scale and emotional fireworks that made the first film a landmark in his career.                                         A Film Made for the Big Screen ExperienceThe superstar also spoke about the sacredness of the theatrical experience while making Padayappa. He revealed that he consciously resisted lucrative digital offers because he believed the film deserved to be experienced only in cinemas. Except for selling satellite rights, he kept the film away from early home viewing platforms, insisting that its visual energy and narrative punch were designed for the big screen.Directed by KS Ravikumar, the 1999 blockbuster brought together an ensemble that still feels timeless. Sivaji Ganesan delivered regal gravitas as Padayappa’s father, while Soundarya offered warmth and restraint opposite Rajinikanth. Radha Ravi, Nassar, Manivannan, and Abbas rounded out a cast that propelled the story’s blend of conflict, romance, and redemption.                                                                 View this post on Instagram          A post shared by Soundarya Rajinikanth (@soundaryaarajinikant)               AR Rahman’s soundtrack was a sensation on release and remains one of his enduring commercial albums. Tracks like En Peru Padayappa and Minsara Poove continue to dominate nostalgic playlists, testimony to the musical legacy that accompanied the film’s theatrical impact.More than 25 years later, Padayappa still represents everything that makes mass cinema a communal celebration. The emotion, the punch lines, the star power, and the myth making around Rajinikanth have aged into legend. Its rerelease arrives at a symbolic moment in his career, allowing audiences to relive the energy that once turned theatres into festival grounds.And if a Neelambari centred sequel does take shape, fans may soon witness a fresh chapter in one of Tamil cinema’s most iconic rivalries.Also Read: Tamil Cinema Bids Farewell to AVM Saravanan, A Producer Who Shaped Generations。    

    Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province. Photo: Scrrenshot from website
A Chinese research team has identified a new potential target to develop antidepressant drug from Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province, according to Kunming University of Science and Technology, Science and Technology Daily reported Sunday.
The team, led by professors Xu Tianrui and Xiang Cheng from the university's School of Life Science and Technology, found that Qingyangshen glycosides, the plant's core active compound, can alleviate depression-related behaviors by simultaneously suppressing inflammation, reducing oxidative damage and stabilizing neurotransmitters in the brain.
The findings were published in the international journal Phytomedicine.  
Depression has become a widespread mental health disorder globally, while existing clinical drugs fail to provide effective treatment for more than 30 percent of patients, according to the researchers. Previous studies have established a strong link between chronic inflammation and depression, but existing anti-inflammatory drugs have limited targeting capabilities, underscoring the need for new therapeutic targets and lead compounds.
Qingyangshen, a plant of the Cynanchum genus in the Apocynaceae family, has long been used as a traditional medicine by ethnic groups including the Naxi, Yi and Bai peoples in Yunnan, mainly for treating neurological conditions such as epilepsy and neurasthenia. 
The researchers systematically examined the pharmacological effects of Qingyangshen extract and its core active compound, Qingyangshen glycosides. Tests using mouse, zebrafish and fruit fly models repeatedly showed that the compound significantly improved depression-related behaviors induced by inflammation, according to the report.
To identify the compound's target, the team developed a dual-discrimination model for four subtypes of prostaglandin E2 receptors and combined it with AI-powered machine learning. The researchers screened hundreds of G protein-coupled receptors and identified the prostaglandin E2 subtype 4 receptor as the direct target of Qingyangshen glycosides.
Multiple molecular experiments confirmed that the compound binds directly to the receptor and acts as an inhibitory ligand. Further experiments involving animals with the receptor knocked out in the hippocampus showed that the antidepressant effects of Qingyangshen glycosides disappeared completely when the receptor was absent, providing the first in-vivo evidence that the receptor is essential for the compound's therapeutic effects.
    An illustration of the research. Photo: Screenshot from the website
The study establishes the prostaglandin E2 subtype 4 receptor as a potential new target for antidepressant drug development and points to a new approach to treating depression through inflammatory pathways. It also identifies Qingyangshen glycosides as a potential lead compound for developing highly targeted anti-inflammatory antidepressants, creating a research chain from ethnic medicinal plants and active compounds to drug targets and new drug development.
Global Times
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