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China approves first-ever drug for acute mountain sickness prevention_我的网站

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    Medicine File photo: VCG
China has granted marketing approval of its first drug for the prevention of acute mountain sickness, filling the long-standing gap in the domestic market where no such medications had been available, Science and Technology Daily reported on Tuesday.
The National Medical Products Administration (NMPA) has approved the marketing of acetazolamide sustained-release capsules, the report said. As the first specialized drug in China indicated for preventing of acute mountain sickness, its approval marks the end of the country's lack of dedicated preventive treatment for altitude illness. 
By inhibiting the activity of carbonic anhydrase, acetazolamide promotes the renal excretion of bicarbonate, corrects respiratory alkalosis caused by hypoxia at high altitudes, thereby regulating acid-base balance, optimizing respiratory status, elevating blood oxygen levels, and reducing the risk of onset at the source. 
In contrast to health products that only provide auxiliary regulatory effects, this medication has been validated through stringent clinical trials and stands as a specialized drug approved by the NMPA with a clear indication for prevention, said the report.
Led by principal investigator is Luobu Gesang, a deputy dean of the People's Hospital of Xizang Autonomous Region, the clinical trial was designed by his team and has yielded critical evidence to inform prevention strategies for altitude sickness that are specifically adapted to Chinese and Asian populations. 
"Previously, although acetazolamide had already been used internationally for the prevention of acute mountain sickness, China had long lacked an NMPA-approved acetazolamide formulation supported by rigorous clinical trials. Furthermore, the existing international formulations were short-acting tablets requiring multiple daily doses, and no drugs with the relevant indication were available on the domestic market for an extended period," said Luobu Gesang.
The sustained-release capsule approved this time not only fills this critical gap but also optimizes the dosage form, providing more reliable and convenient medication protection for the physical health and life safety of people entering high-altitude areas, he added.
Clinical trials showed that, compared with the placebo group, the incidence of acute mountain sickness in the medication group was significantly reduced, with the incidence of moderate-to-severe acute mountain sickness decreasing by 14.6 percent, according to the report.
Related research has been published in the international flagship journal of high-altitude medicine, High Altitude Medicine & Biology.
Global Times
。    据New Atlas报道，塑料可以是硬的，也可以是软的，但塑料可以同时具有这两种特性吗？得克萨斯大学奥斯汀分校的科学家们一直在探索这个问题，并生产出一种首创的材料，这种材料在某些部分是柔韧的，而在其他部分是坚硬的，他们认为有一天这种材料会被用于柔性电子产品和机器人。在开发这种新型材料时，科学家们从天然材料中获得了灵感，这些材料在某些地方是刚性的，而在其他地方则是柔软和有弹性的。皮肤、肌肉、树木和贝类是该团队提供的几个例子，但是创造出混合强度和灵活性的合成版本是很困难的。

B | 以前的方法包括将不同的材料混合在一起，但这有其缺点，成品往往在接缝处散开。研究人员声称，在材料科学的这一分支中，一种新型的类似塑料的材料取得了突破。

C | 作为一个起点，化学家们使用了单体，即聚集在一起形成聚合物的小分子。在这种情况下，聚合物与常用塑料中的聚合物非常相似，但有一两个特殊的技巧。在测试了十几种候选材料后，科学家们发现了一种催化剂，它可以被整合到单体中，使它们对可见光产生反应，用廉价的蓝色LED来传递。这产生了创造一种半结晶聚合物的效果，其属性类似于橡胶，形成一种坚硬的材料。同时，没有暴露在光线下的区域仍然是柔软和有弹性的。“这是同类材料中的第一种，”化学助理教授和论文的通讯作者Zachariah Page说。“通过应用光来控制结晶，并因此控制材料的物理特性的能力，对于可穿戴电子设备或软体机器人的执行器来说，可能是一种变革。”研究人员称，这种类似塑料的材料的韧性是天然橡胶的10倍，但在不同区域具有不同的物理特性。

D | 科学家们想象他们的创造有广泛的应用，包括固定可穿戴技术或医疗设备中的电子元件，以及改善机器人的强度和灵活性。研究第一作者Adrian Rylski说：“我们期待着探索应用这种化学方法来制造包含软硬成分的3D物体。

E | ”这项研究发表在《科学》杂志上。

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Published on:13:45:38